Chromatography Media — The Core of Biopharmaceutical Purification

Recombinant Proteins · Native Proteins · Viral Vaccines · Diagnostic Antibodies and Antigens · Therapeutic Antibodies

 

With the advancement of biotechnology, the global biopharmaceutical market has experienced rapid growth. Antibody-based drugs have become the best-selling and fastest-growing category of pharmaceuticals. At present, China’s high-end biopharmaceutical market has become one of the most promising markets in the global pharmaceutical industry.

 

Zhengguang’s technological expertise and product portfolio in the biopharmaceutical sector are well aligned with the golden development period of China’s biopharmaceutical industry during the 15th Five-Year Plan, as the country advances from being a major pharmaceutical producer to becoming a global pharmaceutical powerhouse.

 

Through this strategic positioning, Zhengguang is becoming a key provider of critical materials supporting innovation and industrial upgrading within the biopharmaceutical industry.

 

Chromatographic separation media (resins/packings) are regarded as the“soul” of biopharmaceutical separation and purification. They are porous microspherical materials with specific pore sizes and separation characteristics, widely used in the field of biological separation and purification.

 

These materials play an important role in industries such as synthetic biology, biocatalytic enzymes, medical aesthetic proteins, functional foods and nutraceuticals, animal vaccines, hemodialysis, diagnostic enzymes and antibodies, and monoclonal antibodies. The type and properties of chromatography media have become critical factors in improving the efficiency of bioprocess separation and purification.

 

The separation performance of chromatography media mainly depends on the adsorption and desorption interactions between the components in the sample and the stationary phase.

 

During the chromatographic process, the sample is carried by the mobile phase through the packed bed of the chromatographic medium. Because different components exhibit different affinities toward the stationary phase, they undergo varying degrees of adsorption and desorption, thereby achieving separation.

 

 

Zhengguang Biotech specializes in providing core purification products and solutions for the research, development, and manufacturing of biotechnology and biopharmaceuticals.

 

Its product portfolio includes a new generation of “uniform particle” agarose-based and polymer-based chromatography media, covering ion exchange, hydrophobic interaction, and affinity chromatography resins.

 

01 Agarose-Based Chromatography Media

High capture efficiency, high binding capacity, high flow rate, and enhanced pressure resistance.

 

The Thoth™ series represents a new generation of uniform-particle agarose-based chromatography media, manufactured using our proprietary “Array Jetting Technology.” With customizable particle sizes and a high degree of particle uniformity, these media provide more efficient purification performance and are well suited for the large-scale purification of monoclonal antibodies, recombinant proteins, and vaccines.

 

The Cheta™ series consists of conventional agarose-based chromatography media, designed for broad applications in biomolecule purification. This series offers customers a cost-effective solution while maintaining reliable purification performance.

 

02 Polymer Series Chromatography Media

Ultra-high resolution, high binding capacity, and enhanced pressure resistance.

 

The Polix™ series of macroporous polymer-based chromatography media provides additional options for biomolecule purification. It can be used in combination with agarose-based products to achieve optimal process optimization.

 

03 Prepacked Columns Series and Research Series

During the R&D stage and in laboratory research applications, we also provide a wide range of prepacked column products and customized solutions to meet customers’ needs for rapid process development and specialized applications.

 

Leveraging innovative chromatography purification technologies, Zhengguang Biotech continues to support biopharmaceutical companies in optimizing downstream purification processes and has developed dozens of highly selective purification media. Through mechanisms such as size exclusion chromatography (SEC) and ion exchange chromatography (IEX), efficient separation of biomacromolecules such as proteins and nucleic acids can be achieved, significantly improving product purity and biological activity.

 

At the same time, we help customers rapidly screen the optimal products, shorten process development cycles, and accelerate drug development and commercialization, ultimately bringing greater benefits to human health.